SAHV European & international Research Alliance

SAHVERA

One shared measure of subarachnoid hemorrhage, across continents. SAHVERA links centers that contribute de-identified imaging and outcomes to validate SAH volume (SAHV) and build explainable AI for non-contrast head CT.

8Sites
5Countries
4Continents

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Participating Sites

Centers and investigators building a shared SAHV evidence base

Mayo Clinic Florida

Jacksonville, Florida, USA

Coordinating center
WF
W. David Freeman, MD Principal Investigator
Neurocritical Care

Baptist Neurological Institute

Lyerly Neurosurgery, Baptist Medical Center, Jacksonville, Florida, USA

Validation site
RH Headshot of Ricardo Hanel, MD, PhD
Ricardo Hanel, MD, PhD Neurosurgery
Lyerly Neurosurgery, Baptist Jacksonville
NN
Neeraj Naval, MD Lyerly Neurosurgery
Baptist Jacksonville

Also at Baptist / Lyerly: Eric Sauvageau, MD · Amin Aghaebrahim, MD · Otavio Frederico de Toledo, MD · Salvador F. Gutierrez-Aguirre, MD · Montserrat Lara-Velazquez, MD

Contributed consecutive SAH cases to the multicenter eSAH validation using the SAHV (model 1) ABC/2 method.

University of Washington

Department of Neurology, Seattle, Washington, USA

Welcome
VL Headshot of Victor Lin, MD
Victor Lin, MD Assistant Professor of Neurology
Neurointensivist, Neurocritical Care
BM Headshot of Thabele M. (Bay) Leslie-Mazwi, MD
Bay Leslie-Mazwi, MD Chair, Department of Neurology
Professor of Neurology

Creighton University

Department of Neurology, Omaha, Nebraska, USA

Welcome
RS
Rohan Sharma, MD Assistant Professor of Neurology and Critical Care Medicine
Creighton University · SAHVAI researcher (remote)

Formerly at Mayo Clinic Florida, where he worked on the SAHV ABC/2 and eSAH validation studies. Continues as a remote SAHVAI researcher.

Federal University of São Paulo

Neurology and Neurosurgery (UNIFESP), São Paulo, Brazil

SAHV-BRaZA

Brazilian SAHV-BRaZA site. Contributed consecutive SAH cases to the multicenter eSAH validation using the SAHV (model 1) ABC/2 method.

Nanchang University

BrainHemoAI Group, Second Affiliated Hospital, Nanchang, Jiangxi, China

Welcome
XZ
Professor Xingen Zhu Senior investigator, BrainHemoAI
Department of Neurosurgery, The Second Affiliated Hospital of Nanchang University
PH Headshot of Ping Hu
Ping Hu, MD Core Member, BrainHemoAI Research Team
Sub-I, PROSAH-MPC Multi-center Cohort Study
Attending Physician, Department of Neurosurgery, The Second Affiliated Hospital of Nanchang University

Key paper: Hu P, et al. Deep learning-assisted identification and quantification of aneurysmal subarachnoid hemorrhage in non-contrast CT scans: development and external validation of Hybrid 2D/3D UNet. NeuroImage 2023;279:120321. PubMed · DOI

Helsinki University Hospital

Neurocenter, Division of Neurosurgery, Helsinki, Finland

Welcome
BJ Headshot of Behnam Rezai Jahromi, MD, PhD
Behnam Rezai Jahromi, MD, PhD Associate Professor
Consultant Neurosurgeon
President, ACE Society

Behnam Rezai Jahromi, MD, PhD, is a neurosurgeon and researcher at Helsinki University Hospital and the University of Helsinki in Finland. His clinical focus is neurovascular surgery and microneurosurgery, along with biological approaches to modifying cerebrospinal fluid. He is the international principal investigator of the ARCH and VASH trials, holds several patents, and has contributed to more than 200 publications and 35 book chapters. He also serves as President of the ACE Society, where he leads its educational programs and international collaborations.

Río Hortega University Hospital

Neurovascular Unit, Department of Neurosurgery · GEIBAC, IBioVALL, Valladolid, Spain

Welcome
SC Headshot of Santiago Cepeda, MD, PhD
Santiago Cepeda, MD, PhD Attending Neurosurgeon, Neurovascular Unit
Lead, GEIBAC (Specialized Group in Biomedical Imaging and Computational Analysis), IBioVALL

Santiago Cepeda, MD, PhD, is an attending neurosurgeon in the Neurovascular Unit of the Department of Neurosurgery at Río Hortega University Hospital in Valladolid, Spain. He trained in neurosurgery at 12 de Octubre University Hospital in Madrid, earned his PhD cum laude from Complutense University of Madrid, and holds a Diploma in Translational Oncology. He also leads GEIBAC (Specialized Group in Biomedical Imaging and Computational Analysis) at IBioVALL. As a computational neurosurgeon, he combines clinical practice with hands-on AI development: he designs, codes and deploys his own machine learning tools for medical imaging, a combination that is still rare in the field. His tools include Mortality-SAH and CereBleed for subarachnoid and intracranial hemorrhage, as well as models for glioblastoma and intraoperative ultrasound.

Tools: CereBleed · Mortality-SAH · GEIBAC lab

Key papers: CereBleed. Neurosurgery 2026. DOI · Mortality-SAH. Neurosurgery 2026. DOI

Mayo Clinic Rochester (Minnesota) is part of the Mayo SAHVAI team and appears on the globe as a linked node. Brazil and Baptist sites: external multicenter validation of the eSAH score, Sci Rep 2025.

Interfacing with

CODE ICH

Intracerebral and subarachnoid hemorrhage share the same first problem: finding and measuring blood on a head CT, fast and the same way everywhere. SAHVERA is designed to interface with the CODE ICH group so that volumetric measurement, AI tools and trial-ready data standards can be shared across hemorrhagic stroke.

  • Common hemorrhage volumetrics and reporting language
  • Shared imaging pipelines and AI validation approaches
  • Aligned governance for multi-site, de-identified data
  • ACE (Active Cerebrospinal fluid Exchange) Investigators bridge the two groups: active CSF exchange as a shared approach to clearing blood in SAH and ICH
Visit code-ich.org

SAHVERA & Future Trials

From a shared volumetric measure to prospective, outcome-driven trials

SAHVERA

SAH Volumetric Endpoints for Risk Assessment

A proposed future multi-omics trial investigating radiomics of imaging, clinomics, metabolomics, and other laboratory data on SAH outcomes.

  • Radiomics
  • Clinomics
  • Metabolomics
  • Laboratory data

Future trial · 2027–2028

SAHVER

SAH Volumetric Expedited Resolution

Exploring the use of active CSF irrigation versus EVD on outcomes.

  • Active CSF irrigation
  • vs. EVD
  • Outcomes

Join SAHVERA

Bring your center into the alliance

What members receive

  • Access to multi-site, de-identified SAH imaging datasets
  • Validated SAHV tools for research and clinical trials
  • Collaboration with leading international researchers
  • Rigorous data privacy and governance frameworks
  • Contribution to open, auditable AI methods